Luca Fabris Selected Research

Congenital Hepatic Fibrosis

1/2022	Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1-/- mouse model of congenital hepatic fibrosis.
1/2018	β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis.
11/2013	Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis.

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Luca Fabris Research Topics

Disease

15	Cholangiocarcinoma 01/2022 - 09/2011
15	Neoplasms (Cancer) 01/2022 - 09/2011
12	Fibrosis (Cirrhosis) 01/2022 - 12/2008
11	Cysts 01/2022 - 05/2006
10	Liver Diseases (Liver Disease) 01/2022 - 03/2003
10	Inflammation (Inflammations) 01/2022 - 10/2011
6	Polycystic liver disease 06/2021 - 01/2010
5	Sclerosing Cholangitis 01/2022 - 03/2003
5	Cholestasis 01/2020 - 03/2003
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020 - 03/2016
4	Cystic Fibrosis (Mucoviscidosis) 01/2019 - 10/2011
3	Congenital Hepatic Fibrosis 01/2022 - 11/2013
3	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2019 - 12/2008
3	Autosomal Dominant Polycystic Kidney (ADPKD) 01/2017 - 05/2006
3	Hypoxia (Hypoxemia) 12/2015 - 01/2010
2	Insulin Resistance 01/2022 - 01/2011
2	Carcinogenesis 01/2022 - 01/2022
2	Autosomal Recessive Polycystic Kidney (Polycystic Kidney Disease, Infantile, Type I) 01/2021 - 01/2018
2	Hyperplasia 01/2020 - 01/2019
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 01/2018
2	Body Weight (Weight, Body) 05/2010 - 01/2010
1	Overweight 01/2022
1	Choledocholithiasis 01/2022
1	Disease Progression 01/2022
1	Obesity 01/2022
1	Hepatitis 01/2022
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 01/2021
1	Ciliopathies 01/2021
1	Rare Diseases (Rare Disease) 01/2021
1	Chronic Hepatitis (Chronic Active Hepatitis) 11/2020
1	Non-alcoholic Fatty Liver Disease 11/2020
1	Reperfusion Injury 01/2020
1	Type 2 Diabetes Mellitus (MODY) 01/2019
1	Lymphatic Metastasis 01/2019

Drug/Important Bio-Agent (IBA)

7	Biomarkers (Surrogate Marker)IBA 01/2022 - 12/2015
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2003
7	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2021 - 05/2006
5	CytokinesIBA 01/2020 - 03/2003
5	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2019 - 03/2003
5	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2018 - 03/2012
4	CateninsIBA 01/2022 - 11/2013
4	ChemokinesIBA 01/2022 - 03/2017
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 12/2015
3	Pharmaceutical PreparationsIBA 01/2022 - 09/2015
3	Adenosine Monophosphate (AMP)IBA 12/2015 - 03/2003
3	TRPP Cation ChannelsIBA 12/2012 - 05/2010
3	Proliferating Cell Nuclear Antigen (PCNA)IBA 05/2010 - 05/2006
2	clonidine-displacing substance (ClDS)IBA 11/2020 - 01/2020
2	Platelet-Derived Growth FactorIBA 01/2019 - 09/2013
2	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 03/2017
2	Keratin-19 (Keratin 19)IBA 01/2018 - 10/2011
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2017 - 03/2003
2	1-dodecylpyridoxal (PLD)IBA 01/2017 - 03/2012
2	Calcium-Binding ProteinsIBA 01/2016 - 09/2011
2	Mitogen-Activated Protein Kinase 3IBA 12/2015 - 01/2010
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 12/2012 - 03/2012
2	TOR Serine-Threonine KinasesIBA 03/2012 - 05/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2010 - 03/2003
2	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 01/2010 - 05/2006
1	6-propylchromone-2-carboxylic acid (PCCA)IBA 01/2022
1	Connective Tissue Growth FactorIBA 01/2022
1	AdipokinesIBA 01/2022
1	Biological ProductsIBA 01/2022
1	pevonedistatIBA 01/2022
1	Tryptophan HydroxylaseIBA 01/2020
1	Monoamine Oxidase (MAO)IBA 01/2020
1	Serotonin ReceptorsIBA 01/2020
1	Serotonin (5 Hydroxytryptamine)IBA 01/2020
1	obeticholic acidIBA 01/2020
1	Matrix Metalloproteinases (MMPs)IBA 01/2020
1	IncretinsIBA 01/2019
1	Conditioned Culture MediaIBA 01/2019
1	Toll-Like Receptor 4IBA 01/2019
1	MelatoninIBA 01/2019
1	Secretin FDA Link 01/2019
1	InflammasomesIBA 01/2019
1	Arylalkylamine N-AcetyltransferaseIBA 01/2019
1	Hormones (Hormone)IBA 01/2019
1	Bicarbonates (Hydrogen Carbonate)IBA 01/2019
1	Vascular Endothelial Growth Factor CIBA 01/2019
1	secretin receptorIBA 01/2019
1	navitoclaxIBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2018
1	EnzymesIBA 01/2018
1	src-Family KinasesIBA 01/2018
1	N- (1- (3- (4- ethoxyphenyl)- 4- oxo- 3,4- dihydropyrido(2,3- d)pyrimidin- 2- yl)ethyl)- N- pyridin- 3- ylmethyl- 2- (4- trifluoromethoxyphenyl)acetamideIBA 01/2018
1	CXCR ReceptorsIBA 01/2018
1	Chemokine CXCL10IBA 01/2018
1	Monomeric GTP-Binding ProteinsIBA 01/2018
1	Bile Acids and Salts (Bile Acids)IBA 01/2018
1	ChromatinIBA 01/2018
1	Ligases (Synthetase)IBA 01/2018

Therapy/Procedure

10	Therapeutics 01/2022 - 11/2009
4	Drug Therapy (Chemotherapy) 01/2020 - 09/2015
4	Liver Transplantation 01/2019 - 01/2009
2	Ligation 01/2019 - 01/2018
1	Pinealectomy 01/2019
1	Precision Medicine 01/2018
1	Immunotherapy 01/2018